期刊
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
卷 11, 期 1, 页码 85-97出版社
WILEY
DOI: 10.1016/j.dadm.2018.11.003
关键词
Alzheimer's disease; Biomarker; Complement protein; Microglia; Neuroinflammation
资金
- Ministry of Health, Labour, and Welfare of Japan [H23-dementia and fracture-003]
Introduction Amyloid-beta (A beta) clearance is important for damage prevention in Alzheimer's disease. We investigated the utility of A beta clearance proteins as biomarkers for mild cognitive impairment (MCI). Methods Serum apolipoprotein (apo) A-I, compliment protein C3 (C3), transthyretin, and cholesterol levels were measured in 273 subjects, and we analyzed the relationship between these levels and brain atrophy and cerebral blood flow in 63 clinically diagnosed mild cognitive impairment, Alzheimer's disease, and nondemented disease control subjects. Results ApoA-I and transthyretin levels and the active form of C3:native form of C3 ratio achieved an area under the curve of 0.89 (sensitivity: 83%, specificity: 90%) for detecting late mild cognitive impairment. Atrophy was associated with decreased apoA-I and high-density lipoprotein levels. Subjects with reduced cerebral blood flow had lower levels of native form of C3, apoA-I, high-density lipoprotein, and total cholesterol. Low native form of C3 and high active form of C3 levels were found in the hippocampi of patients with Alzheimer's disease. Discussion A beta clearance proteins in the serum are potential biomarkers for mild cognitive impairment evaluation.
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