Evidences for complexations of β-cyclodextrin with some amino acids by 1H NMR, surface tension, volumetric investigations and XRD

Inclusion Composites between (beta-cyclodextrin and amino acids (viz., L-Methionine, L-Proline and L-Glutamine) are established in aqueous medium. Such complexation of amino acids in aqueous medium without using any organic solvent provides great ideas in different industries. The complexes are characterized by H-1 NMR which proves the formation of inclusion complex. The interactions of beta-CD with amino acids are analyzed by means of surface tension and density. Contributions of different groups of the guest molecules to the limiting apparent molar volume are determined. Additionally, the stoichiometry of the inclusion complexes is also determined to be 1:1 in all the three cases. The solid inclusion complex formations of beta-CD with amino acids are confirmed by PXRD analysis.(C) 2017 Elsevier B.V. All rights reserved.