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TERT promoter mutations in melanoma survival
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In Japanese patients with papillary thyroid carcinoma, TERT promoter mutation is associated with poor prognosis, in contrast to BRAF V600E mutation
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Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
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Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC
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Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity
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Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?
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Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
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TERT promoter mutations and telomerase reactivation in urothelial cancer
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The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
Robert J. A. Bell et al.
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Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness
Elisabetta Macerola et al.
VIRCHOWS ARCHIV (2015)
TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma
Mohamed Ali Mosrati et al.
ONCOTARGET (2015)
The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer
Chong Li et al.
ONCOTARGET (2015)
TERT promoter mutations and telomere length in adult malignant gliomas and recurrences
Barbara Heidenreich et al.
ONCOTARGET (2015)
Cancer-associated TERT promoter mutations abrogate telomerase silencing
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Thyroid cancer mortality and incidence: A global overview
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TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas
Matthias Simon et al.
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hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness
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A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression
Linghe Xi et al.
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Endoplasmic reticulum stress activates telomerase
Junzhi Zhou et al.
AGING CELL (2014)
TERT Promoter Mutation as an Early Genetic Event Activating Telomerase in Follicular Thyroid Adenoma (FTA) and Atypical FTA
Na Wang et al.
CANCER (2014)
Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy
Rengyun Liu et al.
ENDOCRINE-RELATED CANCER (2014)
Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome
Yves Allory et al.
EUROPEAN UROLOGY (2014)
Comprehensive Mutation Analysis of the TERT Promoter in Bladder Cancer and Detection of Mutations in Voided Urine
Carolyn D. Hurst et al.
EUROPEAN UROLOGY (2014)
TERT Promoter Mutations and Their Association with BRAF V600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer
Xiaoli Liu et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence
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TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy
Ren-Chin Wu et al.
JOURNAL OF PATHOLOGY (2014)
TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma
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An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells
Imke Listerman et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas
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Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma
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The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Imke Listerman et al.
CANCER RESEARCH (2013)
Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma
Xiaoli Liu et al.
CELL CYCLE (2013)
Highly prevalent TERT promoter mutations in aggressive thyroid cancers
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ENDOCRINE-RELATED CANCER (2013)
Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription
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FASEB JOURNAL (2013)
Frequent Somatic TERT Promoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells
Z. Liu et al.
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Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis
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TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism
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TERT Promoter Mutations in Familial and Sporadic Melanoma
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Highly Recurrent TERT Promoter Mutations in Human Melanoma
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Frequency of TERT promoter mutations in human cancers
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High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
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NATURE COMMUNICATIONS (2013)
Human telomerase represses ROS-dependent cellular responses to Tumor Necrosis Factor-α without affecting NF-κB activation
Marina Mattiussi et al.
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Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer
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Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation
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Telomerase directly regulates NF-κB-dependent transcription
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Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling
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Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
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NF-kappaB p65 modulates the telomerase reverse transcriptase in the HepG2 hepatoma cell line
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Phenotypes in mTERT+/- and mTERT-/- Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase
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Forced Activation of β-Catenin Signaling Supports the Transformation of hTERT-Immortalized Human Fetal Hepatocytes
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Separation of telomerase functions by reverse genetics
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Maintenance of tumor initiating cells of defined genetic composition by nucleostemin
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Nuclear Factor κB-Mediated Transactivation of Telomerase Prevents Intimal Smooth Muscle Cell From Replicative Senescence During Vascular Repair
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Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo
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IFN-γ/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer
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CTCF binds the proximal exonic region of hTERT and inhibits its transcription
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Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice
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MOLECULAR AND CELLULAR BIOLOGY (2004)
Genetic and epigenetic modulation of telomerase activity in development and disease
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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
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Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests
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The thyroid nodule
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Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
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Expression profile of a γ-deletion variant of the human telomerase reverse transcriptase gene
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Telomerase contributes to turnorigenesis by a telomere length-independent mechanism
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Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
E González-Suárez et al.
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Human telomerase and its regulation
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MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2002)
Constitutive telomerase expression promotes mammary carcinomas in aging mice
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Switching and signaling at the telomere
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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
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NF-κB regulates transcription of the mouse telomerase catalytic subunit
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Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization
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The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function
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