期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 58, 期 2, 页码 R129-R146出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-16-0195
关键词
cancer; telomerase; thyroid; TERT
资金
- FCT, the Portuguese Foundation for Science and Technology [SFRH/BD/110617/2015, SFRH/BD/81940/2011]
- FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE Operacional Programme for Competitiveness and Internationalization (POCI), Portugal
- Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia/Ministerio da Ciencia, Tecnologia e Inovacao in the framework of the project 'Institute for Research and Innovation in Health Sciences' [POCI-01-0145-FEDER-007274]
- project 'Advancing cancer research: from basic knowledgment to application'
- Projetos Estruturados de IDI
- Norte Programa Operacional Regional do Norte
- [NORTE-01-0145-FEDER-000029]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/110617/2015, SFRH/BD/81940/2011] Funding Source: FCT
Evasion of replicative senescence and proliferation without restriction, sometimes designated as immortalisation, is one of the hallmarks of cancer that may be attained through reactivation of telomerase in somatic cells. In contrast to most normal cells in which there is lack of telomerase activity, upregulation of TERT transcription/activity is detected in 80-90% of malignant tumours. In several types of cancer, there is a relationship between the presence of TERT promoter mutations, TERT mRNA expression and clinicopathological features, but the biological bridge between the occurrence of TERT promoter mutations and the aggressive/invasive features displayed by the tumours remains unidentified. We and others have associated the presence of TERT promoter mutations with metastisation/survival in several types of cancer. In follicular cell-derived thyroid cancer, such mutations are associated with worse prognostic features (age of patients, tumour size and tumour stage) as well as with distant metastases, worse response to treatment and poorer survival. In this review, we analyse the data reported in several studies that imply TERT transcription reactivation/activity with cell proliferation, tumour invasion and metastisation. A particular attention is given to the putative connections between TERT transcriptional reactivation and signalling pathways frequently altered in cancer, such as c-MYC, NF-kappa B and B-Catenin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据