期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 61, 期 1, 页码 T45-T60出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-17-0250
关键词
sarcomas; IGF system; targeted therapy; clinical trials
资金
- Italian Association for Cancer Research [IG2016_18451]
- Istituto Ortopedico Rizzoli (5xmille contributions to the Rizzoli Institute)
- Fondazione Italiana per la Ricerca sul Cancro-FIRC (FIRC project) [17984]
- Guido Berlucchi Foundation
The insulin-like growth factor (IGF) system has gained substantial interest due to its involvement in regulating cell proliferation, differentiation and survival during anoikis and after conventional and targeted therapies. However, results from clinical trials have been largely disappointing, with only a few but notable exceptions, such as trials targeting sarcomas, especially Ewing sarcoma. This review highlights key studies focusing on IGF signaling in sarcomas, specifically studies underscoring the properties that make this system an attractive therapeutic target and identifies new relationships that may be exploited. This review discusses the potential roles of IGF2 mRNA-binding proteins (IGF2BPs), discoidin domain receptors (DDRs) and metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) in regulating the IGF system. Deeper investigation of these novel regulators of the IGF system may help us to further elucidate the spatial and temporal control of the IGF axis, as understanding the control of this axis is essential for future clinical studies.
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