期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 429, 期 18, 页码 2747-2751出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2017.06.025
关键词
adenovirus structure; hexon; protein IX; molecular mold; protein network
资金
- National Institutes of Health [R01A1070771, R21A1103692]
Adenoviruses are respiratory, ocular and enteric pathogens that form complex capsids, which are assembled from seven different structural proteins and composed of several core proteins that closely interact with the packaged dsDNA genome. The recent near-atomic resolution structures revealed that the interlacing continuous hexagonal network formed by the protein IX molecules is conserved among different human adenoviruses(HAdVs), but not in non-HAdVs. In this report, we propose a distinct role for the hexon protein as a molecular mold in enabling the formation of such hexagonal protein IX network that has been shown to preserve the stability and infectivity of HAdVs. (C) 2017 Elsevier Ltd. All rights reserved.
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