期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 111, 期 -, 页码 40-50出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2017.08.002
关键词
Exosome; Microvesicle; Mesenchymal stem cell; Cardioprotection; Cardiac injury; Biomarker
资金
- VA Merit Award
- [HL077281]
- [HL079071]
Exosomes have an evolving role in paracrine and autocrine signaling, which is enhanced because these lipid vesicles are quite stable and can deliver miRNA, DNA, protein and other molecules to cells throughout the body. Most cell types release exosomes, and exosomes are found in all biological fluids, making them accessible biomarkers. Significantly, exosomes can carry a biologically potent cargo, which can alter the phenotype of recipient cells. In the cardiovascular system exosomes have been primarily studied for their role in mediating the beneficial effects of mesenchymal stem cells after myocardial injury. Exosomes released by cardiac cells in disease states, such as myocardial ischemia, can potentially have important pathophysiologic effects on other cardiac cells as well as on distant organs. Published by Elsevier Ltd.
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