期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 45, 页码 9766-9771出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01868a
关键词
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资金
- National Natural Science Foundation of China [21772001]
- Anhui Provincial Natural Science Foundation [1808085MB41]
- Special and Excellent Research Fund of Anhui Normal University
A facile and efficient synthetic strategy for the chemoselective synthesis of N-substituted 3-aryl-1H-pyrazole derivatives has been developed, and it was oriented by different 2-diazo compounds. Both N-H insertion and Wolff-rearrangement products can be obtained selectively by the opportune choice of diazo compounds. N-Cyclohexenone 3-aryl-1H-pyrazoles were formed using cyclic 2-diazo-1,3-diketones via N-H insertion in the presence of a copper catalyst, and alpha-carbonyl 3-aryl-1H-pyrazoles could be synthesized through a Wolff-rearrangement process without any catalyst under thermal conditions. Moreover, both reactions could be carried out in moderate to excellent yields (58-93%) and showed good functional group tolerance.
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