期刊
JOURNAL OF MEMBRANE BIOLOGY
卷 250, 期 5, 页码 471-481出版社
SPRINGER
DOI: 10.1007/s00232-017-9973-y
关键词
Autonomic regulation; Cardiac electrophysiology; Temperature
资金
- British Heart Foundation [FS/12/11/29289]
- National Institute for Health Research Barts Cardiovascular Biomedical Research Unit
- BHF programme Grant [RG/15/15/31742]
- Federation Francaise de Cardiologie et Fondation Coeur et Arteres
- British Heart Foundation [RG/15/15/31742, FS/12/11/29289] Funding Source: researchfish
Cardiac electrophysiology is regulated by the autonomic nervous system, and this has both pathophysiological, and possibly therapeutic importance. Furthermore, chamber differences in electrophysiology exist between atria and ventricles, yet there have been few direct comparisons. There is substantial literature on ion channel modulation at the single-cell level but less work on how this affects tissue-level parameters. We used a microelectrode array system to explore these issues using murine atrial and ventricular tissue slices. Activation time, conduction velocity and repolarisation were measured, and their modulation by temperature and pharmacological autonomic agonists were assessed. The system recorded reliable measurements under control conditions in the absence of drug/thermal challenge, and significant baseline differences were found in chamber electrophysiology. The sodium channel blocker mexiletine, produced large magnitude changes in all three measured parameters. Carbachol and isoprenaline induced differing effects in atria and ventricles, whereas temperature produced similar effects on activation and repolarisation.
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