期刊
JOURNAL OF MEDICINAL FOOD
卷 20, 期 1, 页码 56-64出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2016.3817
关键词
Gentiana macrophylla Pall. (GM); human parvovirus B19 (B19); liver inflammation; nonstructure protein NS1; systematic lupus erythomatosus (SLE)
资金
- Chung Shan Medical University
- Chi-Mei Medical Center [CSMU-CMMC-104-01]
- National Science Council [NSC99-2320-B-040-007-MY3, NSC101-2314-B-040008]
The nonstructural protein NS1 of human parvovirus B19 (B19) is known to exacerbate disease activity in systemic lupus erythematosus (SLE). However, no specific medicine for B19 infection is available. The roots of Gentiana macrophylla Pall. (GM), the traditional Chinese medicine Qinjiao,'' have been used for centuries to treat rheumatic disease, including SLE. Herein, we aimed to investigate the effects of GM root extract (100 and 300 mg/kg body weight) on B19-NS1-exacerbated liver injury in NZB/W F1 mice; liver tissues were assessed by hematoxylin-eosin staining and immunoblotting. The GM root extract significantly decreased B19-NS1-exacerbated liver inflammation by suppressing the expressions of hepatic inducible nitric oxide synthase, cyclooxygenase type 2 (COX-2), interleukin (IL)-1 beta proteins, values of serum asparate transaminase (AST) and alanine transaminase (ALT), and lymphocyte infiltration (P < .05). It also significantly reduced the B19-NS1-exacerbated hepatic matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) expressions by downregulating tumor necrosis factor (TNF)-alpha/NF-kappa B (p65) signaling. These findings suggest a therapeutic potential of GM root extract against B19-NS1-exacerbated liver inflammation in SLE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据