期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 60, 期 13, 页码 5235-5266出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.6b01287
关键词
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资金
- Else-Kroener-Fresenius-Foundation, graduate school Translational Research Innovation-Pharma (TRIP)
- Deutsche Forschungsgemeinschaft (DFG) [PR 1405/2-2, PR 1405/4-1, SFB 1039]
- Landes-Offensive zur Entwicklung Wissenschaftlichokonomischer Exzellenz (LOEWE) of the State of Hessen, Research Center for Translational Medicine and Pharmakology TMP)
Fatty acids beyond their role as an endogenous energy source and storage are increasingly considered as signaling molecules regulating various physiological effects in metabolism and inflammation. Accordingly, the molecular targets involved in formation and physiological activities of fatty acids hold significant therapeutic potential. A number of these fatty acid targets are addressed by some of the oldest and most widely used drugs such as cyclooxygenase inhibiting NSAIDs, whereas Others remain unexploited. Compounds orthosterically binding to proteins that endogenously bind fatty acids are considered as fatty acid mimetics. On the basis of their structural resemblance, fatty acid mimetics constitute a family of bioactive compounds showing specific binding thermodynamics and following similar pharmacokinetic mechanisms. This perspective systematically evaluates targets for fatty acid mimetics, investigates their common structural characteristics, and highlights demands in their discovery and design. In summary, fatty acid mimetics share particularly favorable characteristics justifying the conclusion that their therapeutic potential vastly outweighs the challenges in their design.
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