期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 60, 期 10, 页码 4510-4516出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.7b00527
关键词
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资金
- University of Bologna
- Istituto Toscano Tumori
- IG AIRC [18753]
- Fondazione Umberto Veronesi Fellowship
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor,8 and can cross the blood brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor. We also demonstrated in vivo BBB passage and tumor accumulation in a GBM orthotopic model.
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