期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 61, 期 10, 页码 4283-4289出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.7b01120
关键词
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Tackling PPIs, particularly by stabilizing clinically favored conformations of target proteins, with orally available, bona fide small molecules remains a significant but immensely worthwhile challenge for the pharmaceutical industry. Success may be more likely through the application of nature's learnings to build intrinsic rigidity into the design of clinical candidates.
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