期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 60, 期 4, 页码 1605-1610出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.6b01556
关键词
-
资金
- Department of Biotechnology and Council of Scientific and Industrial Research, Government of India, New Delhi [NWP-0036, CSC0123, CSC0302]
In the field of dendritic cell based genetic immunization, previously we showed that liposomes of cationic amphiphiles containing mannose-mimicking shikimoyl headgroup are promising DNA vaccine carriers for dendritic cell (DC) transfection. The present structure activity study reports on the influence of spacer length (between mannose-mimicking headgroups and quaternary nitrogen centers) in modulating the DC-transfection efficiencies. Further, we report on the anti melanoma immune response inducing properties of the promising cationic amphiphiles in syngeneic CS7BL/6J mice under prophylactic settings.
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