期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 7, 期 45, 页码 7176-7183出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb01874c
关键词
-
资金
- Shanghai Science and Technology Development Fund [17XD1421900]
- National Key Research and Development Plan [2016YFC1303103]
- Shanghai Key Laboratory of Molecular Imaging [18DZ2260400]
Recently, a variety of nanoparticles have been widely used as imaging agents or carriers for the diagnosis and therapy of lung cancer. However, their poor imaging effect, high toxicity, pro-inflammatory effect and ineffective treatment are still a great challenge. In this work, we reported a novel kind of BiOI@CuS nanoparticle to achieve safe and effective therapy of lung cancer by co-loading hydrochloric acid doxorubicin (DOX) and aspirin phenacetin and caffeine (APC). The nanoparticles can effectively relieve inflammatory reactions induced by photo-thermal therapy (PTT). In vitro and in vivo assays showed that DOX/APC co-loaded BiOI@CuS exhibited an effective chemo-photothermal comprehensive therapy effect and good CT imaging capability. Consequently, this multifunctional nanosystem provides a versatile and promising platform in the imaging and treatment of lung cancer in further applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据