期刊
JOURNAL OF MEDICAL MICROBIOLOGY
卷 66, 期 1, 页码 1-7出版社
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000391
关键词
Klebsiella pneumoniae; CRP; biofilm formation; capsular polysaccharide; virulence
类别
资金
- Foundation for Innovative Research Team of Hubei Provincial Department of Education [T201612]
- Fund for Fostering the National Natural Science Foundation of Hubei University of Medicine [2012JPY09]
The global regulator cAMP receptor protein (CRP) has been shown to be required for the full virulence and/or for the expression of virulence determinants in a wide set of bacterial pathogens. In this work, the crp mutant as well as the complemented mutant was constructed from a wild-type Klebsiella pneumoniae capsular serotype K1 strain causing the primary pyogenic liver abscess. The phenotypes of wild-type strain, crp mutant and complemented mutant were characterized systematically. It was disclosed that K. pneumoniae CRP was required for the in vitro growth, fimbria production, biofilm formation and lethality in mouse, but it inhibited the capsular polysaccharide biosynthesis. These indicated the important roles of CRP in regulating the expression of virulence and biofilm genes in K. pneumoniae.
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