期刊
JOURNAL OF MEDICAL MICROBIOLOGY
卷 66, 期 10, 页码 1454-1456出版社
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000592
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- POR FESR Sicily grant [DIAMOND- HV CUP: G61I14000010007]
Dissemination of resistance to carbapenems among Enterobacteriaceae through plasmids is an increasingly important concern in health care worldwide. Here we report the first description of an IncX3 plasmid carrying the bla(KPC-3) gene in a strain of Serratia marcescens isolated from a kidney- liver transplanted patient at the transplantation centre ISMETT ( Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione, Palermo, Italy). To localize the transposable element containing the resistance- associated gene Next- Generation Sequencing of the bacterial DNA was performed. S. marcescens was positive for bla(KPC-3) and bla(SHV-11) genes. The molecular analysis demonstrated that the bla(KPC-3) gene of this bacterial strain was located in one copy of the Tn-3-like element Tn4401-a carried in a plasmid that is 53 392 bp in size and showed the typical IncX3 scaffold. Our data demonstrated the presence of a new bla(KPC-3) harbouring the IncX3 plasmid in S. marcescens. The possible dissemination among Enterobacteriaceae of this type of plasmid should be monitored and evaluated in terms of clinical risk.
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