期刊
DALTON TRANSACTIONS
卷 48, 期 40, 页码 15220-15230出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9dt02571e
关键词
-
资金
- Deutsche Forschungsgemeinschaft (DFG) [Scho 402/12-2]
- Czech Science Foundation [17-05302S]
- University of Bayreuth Graduate School (BayNAT program)
We report 15 new Cu(II) complexes with tridentate NNO beta-acylenamino ligands derived from 2-picolylamine and bearing up to three alkyl, alkoxy, alkoxycarbonyl, or (pseudo)halide substituents. The structures of nine complexes were elucidated by single crystal X-ray diffraction analysis. Complexes with an unsubstituted pyridine ring crystallised with a square pyramidal coordination sphere, whereas substitution of the pyridine ring led to a square planar coordination sphere around the metal centre. The solution structures and properties of the complexes were characterised by UV-Vis spectroscopy and cyclic voltammetry. They were also tested for their cytotoxic effect on four human cancer cell lines. Two complexes were identified that were highly active with single-digit IC50 values, exceeding those of cisplatin by far. A tentative structure-activity relationship was proposed as well as topoisomerase I inhibition as a possible mode of action, while any significant interference with DNA and the level of reactive oxygen species could be excluded.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据