期刊
ISCIENCE
卷 21, 期 -, 页码 68-+出版社
CELL PRESS
DOI: 10.1016/j.isci.2019.10.015
关键词
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资金
- FdF (Fondation de France) [2014_00051580, 2016_00067080]
- ARC (Association pour la Recherche contre le Cancer) [SFE2011_1203807, PJA20181208172]
- GEFLUC - Les Entreprises contre le Cancer
- SATT Sud-Est
- France Life Imaging (French Investissement d'Avenir'' program) [ANR-11-INBS-44-0006]
- Canceropole Provence-Alpes-Cote d'Azur
- FdF fellowship
Computed tomography is a powerful medical imaging modality for longitudinal studies in cancer to follow neoplasia progression and evaluate anticancer therapies. Here, we report the generation of a photon-counting micro-computed tomography (PC-CT) method based on hybrid pixel detectors with enhanced sensitivity and precision of tumor imaging. We then applied PC-CT for longitudinal imaging in a clinically relevant liver cancer model, the Alb-R26(Met) mice, and found a remarkable heterogeneity in the dynamics for tumors at the initiation phases. Instead, the growth curve of evolving tumors exhibited a comparable exponential growth, with a constant doubling time. Furthermore, longitudinal PC-CT imaging in mice treated with a combination of MEK and BCL-XL inhibitors revealed a drastic tumor regression accompanied by a striking remodeling of macrophages in the tumor microenvironment. Thus, PC-CT is a powerful system to detect cancer initiation and progression, and to monitor its evolution during treatment.
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