期刊
HELIYON
卷 5, 期 11, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2019.e02643
关键词
Molecular biology; Cell biology; Biochemistry; Oncology; Pathology; Cancer research; Mantle cell lymphoma; Immunohistochemistry; IFI16; Proliferation; Gene expression
资金
- Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), RFO
- FIRB Futura 2011 [RBFR12D1CB]
- Fondi Dipartimentali
IEI16, member of the IFN-inducible PYHIN-200 gene family, modulates proliferation, survival and differentiation of different cell lineages. In particular, IFI16 expression, which is regulated during the differentiation of B cells, was recently studied in B-CLL as well. Here, we compared IFI16 expression in several lymphomas including Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma with respect to normal cell counterparts. We observed that IEI16 expression was significantly deregulated only in mantle cell lymphoma (p < 0.05). Notably, IEI16 was associated with the expression of genes involved in interferon response, cell cycle, cell death and proliferation and, interestingly, lipid and glucose metabolism, suggesting that IEI16 deregulation might be associated with relevant changes in cell biology. In our group of mantle cell lymphoma samples a correlation between patient survival and IEI16 expression was not detected even though mantle cell lymphoma prognosis is known to be associated with cell proliferation. Altogether, these results suggest a complex relationship between IEI16 expression and MCL which needs to be analyzed in further studies.
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