期刊
NATURE METABOLISM
卷 1, 期 2, 页码 177-188出版社
NATURE RESEARCH
DOI: 10.1038/s42255-019-0032-0
关键词
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资金
- NIH/NCI [K08 CA201483]
- Damon Runyon Cancer Research Foundation [CI 95-18, DFS-23-17]
- Burroughs Wellcome Fund [CAMS 1015584]
- Leukemia & Lymphoma Society [SCOR 7011-16]
- Susan & Peter Solomon Divisional Genomics Program
- Steven A. Greenberg Fund
- Cycle for Survival
- Searle Scholars program
- Starr Foundation [I11-0039]
- Memorial Sloan Kettering Cancer Center Support Grant [P30 CA008748]
In contrast to terminally differentiated cells, cancer cells and stem cells retain the ability to re-enter the cell cycle and proliferate. To proliferate, cells must increase their uptake and catabolism of nutrients to support anabolic cell growth. Intermediates of central metabolic pathways have emerged as key players that influence cell-differentiation 'decisions', processes relevant to both oncogenesis and normal development. Consequently, how cells rewire metabolic pathways to support proliferation can have profound consequences for cellular identity. Here, we discuss the metabolic programs that support proliferation, and we explore how metabolic states are intimately entwined with the cell-fate decisions that characterize stem cells and cancer cells. By comparing the metabolism of pluripotent stem cells and cancer cells, we hope to illuminate common metabolic strategies as well as distinct metabolic features that may represent specialized adaptations to unique cellular demands.
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