期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 46, 页码 9924-9932出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob02126d
关键词
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资金
- Ministerio de Economia y Competitividad (MINECO) [CTQ2016-75023-C2-1-P, CTQ2016-75023-C2-2-P]
- FEDER [CTQ2016-75023-C2-1-P, CTQ2016-75023-C2-2-P, BU291P18]
- Junta de Castilla y Leon [BU291P18, ED418B 2016/166-0]
- Xunta de Galicia [ED431C 2017/70, ED431E 2018/07]
The stereospecific gold(i)-catalyzed nucleophilic cyclization of beta-monosubstituted o-(alkynyl)styrenes to produce C-1 functionalized 1H-indenes including challenging substrates and nucleophiles, such as beta-(cyclo)alkyl-substituted o-(alkynyl)styrenes and a variety of alcohols as well as selected electron-rich aromatics, is reported. DFT calculations support the stereochemical outcome of the process that involves the formation of a key cyclopropyl gold carbene intermediate through a regiospecific 5-endo cyclization.
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