期刊
DIABETES CARE
卷 39, 期 2, 页码 300-307出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc15-1588
关键词
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资金
- National Heart, Lung, and Blood Institute [HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C]
- National Institute on Aging [AG-12975, AG-006781, AG-09769]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK-60753]
- Origins of Variance in the Old-Old: Octogenarian Twins study (The Bank of Sweden Tercentenary Foundation) [P12-0567:1]
- Swedish Research Council for Health, Working Life and Welfare (EpiLife)
- Swedish Research Council for Health, Working Life and Welfare (AGECAP) [2013-2300]
- Grants-in-Aid for Scientific Research [25253048] Funding Source: KAKEN
- Swedish Foundation for Humanities and Social Sciences [P12-0567:1] Funding Source: Swedish Foundation for Humanities and Social Sciences
- Academy of Medical Sciences (AMS) [AMS-SGCL12-Russ] Funding Source: researchfish
- Medical Research Council [MR/K026992/1] Funding Source: researchfish
OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a metaanalysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. RESEARCH DESIGN AND METHODS A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. RESULTS Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45-1.80]; men: pooled RR 1.58 [95% CI 1.38-1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86-2.94) in women and 1.73 (95% CI 1.61-1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35-1.73) in women and 1.49 (95% CI 1.31-1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08-1.30]; P < 0.001). CONCLUSIONS Individuals with type 2 diabetes are at similar to 60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.
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