期刊
DIABETES CARE
卷 38, 期 7, 页码 1306-1311出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc14-3084
关键词
-
资金
- National Institutes of Health [HL-126024, HL-034594, DK-100383, DK-091718, HL-071981, HL-073168, CA-87969, CA-49449, CA-055075, CA-186107, CA-167552]
- American Heart Association Scientist Development Award [0730094N]
- The National Institutes of Health [HL-34594, HL-088521, HL-35464, U01-HG-004399, DK-080140, P30-DK-46200, U01-CA-137088, U54-CA-155626, DK-58845, DK-098311, U01-HG-004728, EY-015473, CA-134958, DK-70756, DK-46200]
OBJECTIVEAbdominal obesity is a major risk factor for type 2 diabetes (T2D). We aimed to examine the association between the genetic predisposition to central obesity, assessed by the waist-to-hip ratio (WHR) genetic score, and T2D risk.RESEARCH DESIGN AND METHODSThe current study included 2,591 participants with T2D and 3,052 participants without T2D of European ancestry from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Genetic predisposition to central obesity was estimated using a genetic score based on 14 established loci for the WHR.RESULTSWe found that the central obesity genetic score was linearly related to higher T2D risk. Results were similar in the NHS (women) and HPFS (men). In combined results, each point of the central obesity genetic score was associated with an odds ratio (OR) of 1.04 (95% CI 1.01-1.07) for developing T2D, and the OR was 1.24 (1.03-1.45) when comparing extreme quartiles of the genetic score after multivariate adjustment.CONCLUSIONSThe data indicate that genetic predisposition to central obesity is associated with higher T2D risk. This association is mediated by central obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据