期刊
DIABETES CARE
卷 38, 期 6, 页码 1099-1107出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc14-2101
关键词
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资金
- National Heart, Lung, and Blood Institute (NHLBI)
- Office of Dietary Supplements of the National Institutes of Health [2R01-HL-085710, R01-HL-085710, R01-HL-094555]
- NHLBI [HL-080295]
- National Institute on Aging [AG-023629]
- U.K. Medical Research Council Epidemiology Unit Core Support [MC_UU_12015/5]
- National Institute of Neurological Disorders and Stroke
- [HHSN268201200036C]
- [HHSN268200800007C]
- [N01-HC-55222]
- [N01-HC-85079]
- [N01-HC-85080]
- [N01-HC-85081]
- [N01-HC-85082]
- [N01-HC-85083]
- [N01-HC-85086]
- MRC [MC_UU_12015/5, MC_UP_A100_1003] Funding Source: UKRI
- Medical Research Council [MC_UP_A100_1003, MC_UU_12015/5] Funding Source: researchfish
OBJECTIVE To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment. RESEARCH DESIGN AND METHODS In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood drawn from 2,919 adults aged 74 +/- 5 years and free of prevalent DM in 1992. Dietary TFA was estimated among 4,207 adults free of prevalent DM when dietary questionnaires were initially administered in 1989 or 1996. Incident DM was defined through 2010 by medication use or blood glucose levels. Risks were assessed by Cox proportional hazards. RESULTS In biomarker analyses, 287 DM cases occurred during 30,825 person-years. Both t-16:1n9 (extreme quartile hazard ratio 1.59 [95% CI 1.04-2.42], P-trend = 0.04) and t-18: 1 (1.91 [1.20-3.03], P-trend = 0.01) levels were associated with higher incident DM after adjustment for de novo lipogenesis fatty acids. In dietary analyses, 407 DM cases occurred during 50,105 person-years. Incident DM was positively associated with consumption of total TFAs (1.38 [1.03-1.86], P-trend = 0.02), t-18: 1 (1.32 [1.00-1.76], P-trend = 0.04), and t-18: 2 (1.41 [1.05-1.89], P-trend = 0.02). After further adjustment for other dietary habits, however, the associations of estimated dietary TFA with DM were attenuated, and only nonsignificant positive trends remained. CONCLUSIONS Among older adults, plasma phospholipid t-16: 1n9 and t-18: 1 levels were positively related to DM after adjustment for de novo lipogenesis fatty acids. Estimated dietary TFA was not significantly associated with DM. These findings highlight the need for further observational, interventional, and experimental studies of the effects TFA on DM.
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