期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 427, 期 -, 页码 81-84出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2016.10.100
关键词
Magnetic microrods; Biofilm; Noncontact manipulation; Infectious disease; Aspergillus
资金
- Maryland NanoCenter
- FabLab
- AIMLab
- Georgetown Nanoscience and Microtechnology Lab
Biofilms are a common and persistent cause of numerous illnesses. Compared to planktonic microbes, biofilm residing cells often demonstrate significant resistance to antimicrobial agents. Thus, methods for dislodging cells from the biofilm may increase the antimicrobial susceptibility of such cells, and serve as a mechanical means of increasing antimicrobial efficacy. Using Aspergillus fumigatus as a model microbe, we magnetically rotate microrods in and around biofilm. We show that such rods can improve the efficacy of antimicrobial Amphotericin B treatments in vitro. This work represents a first step in using kinetic magnetic particle therapy for disrupting fungal biofilms.
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