期刊
FRONTIERS IN MEDICINE
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2019.00276
关键词
kidney transplantation; ischemia-reperfusion injury; normothermic machine perfusion; ischemia-free kidney transplantation; ischemia-free organ transplantation
资金
- National Natural Science Foundation of China [81373156, 81471583, 81570587, 81871257]
- Special Fund for Science Research by Ministry of Health [201302009]
- Key Clinical Specialty Construction Project of National Health and Family Planning Commission of the People's Republic of China
- Guangdong Provincial Key Laboratory Construction Projection on Organ Donation and Transplant Immunology [2013A061401007]
- Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation) [2015B050501002]
- Guangdong Provincial Natural Science Funds for Major Basic Science Culture Project [2015A030308010, 2018A030313612]
- Guangdong Provincial Natural Science Funds for Distinguished Young Scholars [2015A030306025]
- Special Support Program for Training High-Level Talents in Guangdong Province [2015TQ01R168]
- Pearl River Nova Program of Guangzhou [201506010014]
- Science and Technology Program of Guangzhou [201704020150]
Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.
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