4.5 Article

A compound magnetic field generating system for targeted killing of Staphylococcus aureus by magnetotactic bacteria in a microfluidic chip

期刊

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2016.10.109

关键词

Magnetotactic bacteria; Staphylococcus aureus; Swing magnetic field; Targeting therapy; Microfluidic chip

资金

  1. State Key Program of National Natural Science of China [51037006]
  2. National Natural Science Foundation of China [31300689]

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A compound magnetic field generating system was built to kill Staphylococcus aureus (S. aureus) by magnetotactic bacteria (MTB) in a microfluidic chip in this paper. The system was consisted of coil pairs, a switch circuit, a control program and controllable electrical sources. It could produce a guiding magnetic field (gMF) of +/- 1 mT along arbitrary direction in the horizontal plane, a rotating magnetic field (rMF) and a swing magnetic field (sMF, 2 Hz, 10 mT) by controlling the currents. The gMF was used to guide MTB swimming to the S. aureus pool in the microfluidic chip, and then the rMF enhanced the mixture of S. aureus and MTB cells, therefore beneficial to the attachments of them. Finally, the sMF was used to induce the death of S. aureus via MTB. The results showed that MTB could be navigated by the gMF and that 47.1% of S. aureus were killed when exposed to the sMF. It provides a new solution for the targeted treatment of infected diseases and even cancers.

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