期刊
INTEGRATIVE CANCER THERAPIES
卷 18, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735419894061
关键词
prehabilitation; pancreatic cancer; preoperative exercise; physical function; outcome measures
资金
- Knox Family Foundation
- Center for Energy Balance in Cancer Prevention & Survivorship, Duncan Family Institute for Cancer Prevention and Risk Assessment
- Texas Chapter of the American College of Sports Medicine
- Cancer Prevention & Research Institute of Texas Training Grant/MD Anderson Cancer Prevention Research Training Program [RP170259]
- Bettie Willerson Driver Cancer Research Fund
- National Institutes of Health/National Cancer Institute [P30CA016672]
Purpose: To investigate relationships among physical activity, changes in physical function, and health-related quality of life (HRQOL) among patients with pancreatic adenocarcinoma enrolled in a home-based exercise prehabilitation program. Methods: Patients with resectable pancreatic adenocarcinoma receiving preoperative chemotherapy and/or chemoradiation were enrolled on this prospective, single-arm trial and were advised to perform >= 60 minutes each of moderate-intensity aerobic exercise and strengthening exercise weekly. Activity was measured via self-report and accelerometers, including moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), and sedentary activity (SA). Physical function measures at baseline and restaging follow-up included 6-minute walk test (6MWT), 5 times sit-to-stand (5xSTS), handgrip strength (HGS), 3-m walk for gait speed (GS), and the PROMIS Physical Function Short Form. HRQOL was measured via the FACT-Hep questionnaire. Results: Fifty participants with mean age 66 years (standard deviation = 8 years) were enrolled. The 6MWT, 5xSTS, and GS significantly improved from baseline to restaging follow-up (P=.001, P=.049, and P=.009, respectively). Increases in self-reported aerobic exercise, weekly MVPA, and LPA were associated with improvement in 6MWT (beta=.19, P=.048; beta=.18, P=.03; and beta=.08, P=.03, respectively) and self-reported physical functioning (beta=.02, P=.03; beta=.03, P=.005; and beta=.01, P=.02, respectively). Increased weekly LPA was associated with increased HRQOL (beta=.03, P=.02). Increased SA was associated with decreased HRQOL (beta=-.02,P=.01). Conclusions: Patients with potentially resectable pancreatic cancer exhibit meaningful improvement in physical function with prehabilitation; physical activity was associated with improved physical function and HRQOL. These data highlight the importance of physical activity during treatment for pancreatic cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据