期刊
RSC ADVANCES
卷 9, 期 71, 页码 41431-41437出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra08555f
关键词
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资金
- Jilin Province Science and Technology Research Plan [20170204039GX, 20180201085GX]
- National Natural Science Foundation of China [21174052]
- Natural Science Foundation of Jilin Province of China [20170101105JC]
- Provincial Industrial Innovation Special Fund Project of jilin province [2018C052-5]
Near-infrared (NIR) fluorescent probes are widely employed in biological detection because of their lower damage to biological samples, low background interference, and high signal-to-noise ratio. Herein, a highly water-soluble NIR probe (NIRHA) based on a hemicyanine skeleton and bearing an acrylate moiety was synthesized. The probe showed high selectivity toward cysteine (Cys) over homocysteine (Hcy) and glutathione (GSH). The probe also had low cytotoxicity and was successfully applied in HeLa cells and mouse experiments. Results of bioimaging experiments indicated that the probe was effective for visualizing endogenous Cys in vitro and in vivo.
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