期刊
JOURNAL OF LIPID RESEARCH
卷 58, 期 10, 页码 2008-2016出版社
ELSEVIER
DOI: 10.1194/jlr.M078212
关键词
lipoprotein (a); apolipoprotein (a); apolipoproteins; clinical studies; lipoproteins; drug therapy/hypolipidemic drugs; familial hypercholesterolemia; hypercholesterolemic; monoclonal antibody; low density lipoprotein cholesterol reduction; genetic variability; proprotein convertase subtilisin/kexin type 9
资金
- Regeneron Pharmaceuticals
- Sanofi
- University of California, Clinical and Translational Science Center (National Institutes of Health) [UL1TR001860]
- National Institutes of Health K12/Building Interdisciplinary Research Career in Women's Health Program Scholar (National Institutes of Health) [K12HD051958]
An elevated level of lipoprotein (a) [Lp(a)] is a risk factor for CVD. Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9, is reported to reduce Lp(a) levels. The relationship of Lp(a) reduction with apo(a) size polymorphism, phenotype, and dominance pattern and LDL cholesterol (LDL-C) reduction was evaluated in a pooled analysis of 155 hypercholesterolemic patients (75 with heterozygous familial hypercholesterolemia) from two clinical trials. Alirocumab significantly reduced total Lp(a) (pooled median: -21%, P = 0.0001) and allele-specific apo(a), an Lp(a) level carried by the smaller (median: -18%, P = 0.002) or the larger (median: -37%, P = 0.0005) apo(a) isoform, at week 8 versus baseline. The percent reduction in Lp(a) level with alirocumab was similar across apo(a) phenotypes (single vs. double bands) and carriers and noncarriers of a small size apo(a) (<= 22 kringles). The percent reduction in LDL-C correlated significantly with the percent reduction in Lp(a) level (r = 0.407, P < 0.0001) and allele-specific apo(a) level associated with the smaller (r = 0.390, P < 0.0001) or larger (r = 0.270, P = 0.0183) apo(a) sizes. In conclusion, alirocumab-induced Lp(a) reduction was independent of apo(a) phenotypes and the presence or absence of a small size apo(a).
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