期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 102, 期 5, 页码 1261-1269出版社
WILEY
DOI: 10.1189/jlb.4A0317-116R
关键词
plasmablast; B cell help; MR-1; antibody
资金
- National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health [K08AI100923, R01AI130378]
Human MAIT cells have the capacity to provide help to B cells through induction of plasmablast differentiation and antibody production. Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset, restricted by the nonclassic MHC class I-related protein MR1 and enriched at mucosal sites. Human studies have shown an association between MAIT cells and pathogen-specific antibody responses. In this study, we investigate the effect of human MAIT cells on B cells ex vivo. We found that supernatants from microbe- or cytokine-stimulated MAIT cells, when added to purified autologous B cells, increase frequencies of plasmablasts and promote IgA, IgG, and IgM production. We found effects to be mostly MR1-dependent and that the increases in plasmablasts are likely a result of increased differentiation from memory B cells. Furthermore, microbe-activated MAIT cell supernatant contains multiple cytokines known to stimulate B cells, including IL-6, -10, and -21. This study thus provides the first direct evidence of a newly identified role of MAIT cells in providing help to B cells.
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