期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 102, 期 2, 页码 351-360出版社
WILEY
DOI: 10.1189/jlb.5MR1216-534R
关键词
MDSCs; autoimmunity; infection; transplant tolerance; cancer
资金
- U.S. National Institutes of Health National Cancer Institute [R01CA109322, R01CA127483, R01 CA 208703, R01CA140243, R01 CA188610]
Myeloid-derived suppressor cells (MDSCs), a population of immature myeloid cells expanded and accumulated in tumor-bearing mice and in patients with cancer, have been shown to mediate immune suppression and to promote tumor progression, thereby, posing a major hurdle to the success of immune-activating cancer therapies. MDSCs, like their healthy counterparts, such as monocytes/macrophages and granulocytes, express an array of costimulatory and coinhibitory molecules as well as myeloid activators and inhibitory receptors, such as leukocyte immunoglobulin-like receptors (LILR) A and B. This review summarizes current findings on the LILR family members in various diseases, their potential roles in the pathogenesis, and possible strategies to revert or enhance the suppressive function of MDSCs for the benefit of patients by targeting LILRs.
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