期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 102, 期 4, 页码 1017-1034出版社
WILEY
DOI: 10.1189/jlb.5MR0217-059RR
关键词
antigen presentation; T cells; antigen presenting cells; macrophages
资金
- Dutch Cancer Society [VU2013-5940, VU2016-10449, VU2015-7864, VU2014-7200]
There is a growing understanding of why certain patients do or do not respond to checkpoint inhibition therapy. This opens new opportunities to reconsider and redevelop vaccine strategies to prime an anticancer immune response. Combination of such vaccines with checkpoint inhibitors will both provide the fuel and release the brake for an efficient anticancer response. Here, we discuss vaccine strategies that use C-type lectin receptor (CLR) targeting of APCs, such as dendritic cells and macrophages. APCs are a necessity for the priming of antigen-specific cytotoxic and helper T cells. Because CLRs are natural carbohydrate-recognition receptors highly expressed by multiple subsets of APCs and involved in uptake and processing of Ags for presentation, these receptors seem particularly interesting for targeting purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据