期刊
NEUROIMAGE-CLINICAL
卷 24, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2019.102034
关键词
Obsessive-compulsive disorder; Child; Adolescent; Symptom provocation; Neuroimaging
类别
资金
- British Columbia Children's Hospital(BCCH) Foundation
- Michael Smith Foundation for Health Research (MSFHR)
- BC Provincial Health Services Authority (PHSA)
- Canadian Institutes of Health Research (CIHR)
Obsessive-compulsive disorder: (OCD)-affected adults and children exhibit three to four symptom dimensions with distinct but overlapping neural correlates. No symptom provocation behavioural or imaging study has examined all symptom dimensions in a pediatric OCD sample. Method: Clinically diagnosed pediatric OCD-affected participants (n = 25) as well as age, gender and Tanner pubertal stage-matched healthy controls (HCs; n = 24) (total sample: mean age = 14.77 +/- 2.93 years; age range = 9-18 years; 35% male) viewed alternating blocks of OCD symptom provocation (Contamination, Bad Thoughts, and Just Right symptom dimensions), Fear, Neutral and Rest (i.e. fixation) conditions during functional magnetic resonance imaging. A region-of-interest analysis used seeds based upon results of an adult OCD meta-analysis Results: OCD participants found OCD symptom-related stimuli bothersome, particularly when compared to controls in the Just Right symptom dimension. Pediatric OCD patients exhibited greater recruitment of the left superior temporal gyrus (STG) than healthy controls during combined symptom provocation versus neutral conditions. Conclusion: Findings suggest involvement of the temporal poles rather than in classic cortico-striatal-thalamicocortical circuits in pediatric OCD during symptom provocation.
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