期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 32, 期 4, 页码 599-604出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2017.32.4.599
关键词
Behcet's Disease; Human Papilloma Virus; Enzyme-Linked Immunosorbent Assay; IgG Antibody
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2014R1A1A2059503]
- National Research Foundation of Korea [2014R1A1A2059503] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Quadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated with Behcet's disease (BD). However, no reports have described HPV infection as a possible cause for the development of BD. The objective of this study was to evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased in BD. Serum samples from 93 Korean BD patients, who fulfilled the diagnostic criteria of the International Study Group for BD, were used in an enzyme-linked immunosorbent assay (ELISA). The clinical activity of BD was evaluated at the time of blood sampling. HPV-16 L1 virus-like particle (VLP) antigen was used in this study for the ELISA. Patients with BD had significantly higher antibody titers against HPV-16 (optical density [OD], 0.210-3.675; mean 0.992) than that of healthy controls (OD, 0.248-0.762; mean 0.517; P < 0.001). Using a receiver operating characteristic (ROC) analysis, a cut-off value of 0.578 OD for the anti-HPV antibody titer was determined that differentiated BD patients from healthy controls. When we compared the clinical features of BD between the 2 groups, articular involvement of BD was more likely in patients with an anti-HPV-16 antibody titer < 0.578 OD (P = 0.035). In addition, patients with an anti-HPV-16 antibody titer < 0.578 were significantly younger than those with a titer >= 0.578 OD. HPV itself may be a possible extrinsic triggering infectious agent causing the development of BD.
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