期刊
INFECTION AND CHEMOTHERAPY
卷 51, 期 4, 页码 405-413出版社
KOREAN SOC CHEMOTHERAPY
DOI: 10.3947/ic.2019.51.4.405
关键词
Family hantaviridae; Hemorrhagic fever with renal syndrome; Hantavirus; Epidemiology
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2017M3A9E4061992]
- National Research Foundation of Korea [2017M3A9E4061992] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In Korea, hemorrhagic fever with renal syndrome (HFRS) was first reported in a United Nations (UN) soldier stationed in the central front, also known as the Iron Triangle. In 1976, professor Ho Wang Lee discovered an antigen in the lung and kidney tissues of Apodemus agrarius. In 1980, this novel virus was named Hantaan virus after the Hantaan river. The Old World Hantaviruses, which are usually found in East Asia and Europe, are generally transmitted to humans via the respiratory pathway during dry seasons, usually in late spring and fall. Currently, 300 - 600 cases per year are reported in Korea with a mortality rate of 1 - 2%. The typical clinical course of HFRS is classified into five phases: febrile, hypotensive, oliguric, diuretic, and convalescent. And treatment for HFRS is mostly conservative. A vaccine for the Hantaan virus was developed in 1988 and marketed in 1990. Because HFRS outbreaks mostly occur in regions near the truce line in Korea, vaccination is virtually the only protection against the virus among military personnel working in such regions and local residents. Therefore, proving the effectiveness of the HFRS vaccine and devising efficient vaccination plans have been considered a major task for Korea's health authorities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据