期刊
THERAPEUTIC DELIVERY
卷 10, 期 10, 页码 627-642出版社
FUTURE SCI LTD
DOI: 10.4155/tde-2019-0054
关键词
dissolution; microscopy; resveratrol; self-emulsifying drug delivery systems; solubility
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) PICT [0790]
- Universidad Nacional de Cordoba
Aim: A solid self-emulsifying drug delivery systems was developed by using the spray-drying technique, to improve the solubility of resveratrol (RES). Materials & methods: Cod liver oil and three surfactant system were tested: soy phosphatidylcholine (SPC)/Eumulgin (R) HRE-40 (EU)/Sodium oleate (system A); SPC/Tween (R) 80 (TW) /Sodium oleate (system B) and SPC/EU/TW (system C). Results: The greatest incorporation was obtained with system C (21.26 mg/ml). Solid self-emulsifying drug delivery systems with the highest yield were obtained with colloidal silicon dioxide (CSD) (80.12%), and CSD sodium croscarmelose 9:1 and 5:5. RES dissolution attained 100% at 45 min with CSD:CS 5:5. Discussion: The surface modification to hydrophilic by CSD:sodium croscarmellose reduced the cohesive force among drug particles. Conclusion: The developed systems are a good approximation for the design of strategies that could allow increasing the oral bioavailability of RES.
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