期刊
JOURNAL OF MOLECULAR CELL BIOLOGY
卷 11, 期 10, 页码 920-929出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjz033
关键词
alternative splicing; breast cancer; splicing factors; drug resistance; cancer therapeutics
类别
资金
- National Natural Science Foundation of China [81830088, 81422038, 91540110, 31471235, 81872247, 31400726]
- Department of Science and Technology of Dalian City ('Dalian Supports High Level Talents Innovation and Entrepreneurship Program') [2016RJ02]
Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins. Importantly, alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. Based on the statistical data, breast cancer is one of the top leading causes of cancer-related deaths in women worldwide. Strikingly, alternative splicing is closely associated with breast cancer development. Here, we seek to provide a general review of the relationship between alternative splicing and breast cancer. We introduce the process of alternative splicing and its regulatory role in cancers. In addition, we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression. Moreover, we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.
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