期刊
ANTIBIOTICS-BASEL
卷 8, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics8040178
关键词
urea; synthesis; antimicrobial activity; molecular docking; Acinetobacter baumannii
资金
- Florida Gulf Coast University
- American Chemical Society Petroleum Research Fund [58269-ND1]
- DST-Nanomission, India [SR/NM/NS-20/2014]
- DST-SERB, India [SERB/F/1423/2017-18, YSS/2015/000010]
- Jain University, India
- Welcome Trust (UK)
- University of Queensland (Australia)
A series of new urea derivatives, containing aryl moieties as potential antimicrobial agents, were designed, synthesized, and characterized by H-1 NMR, C-13 NMR, FT-IR, and LCMS spectral techniques. All newly synthesized compounds were screened in vitro against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). Variable levels of interaction were observed for these urea derivatives. However, and of major importance, many of these molecules exhibited promising growth inhibition against Acinetobacter baumannii. In particular, to our delight, the adamantyl urea adduct 3l demonstrated outstanding growth inhibition (94.5%) towards Acinetobacter baumannii. In light of this discovery, molecular docking studies were performed in order to elucidate the binding interaction mechanisms of the most active compounds, as reported herein.
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