期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 75, 期 6, 页码 569-583出版社
WILEY-BLACKWELL
DOI: 10.1002/dneu.22267
关键词
cell adhesion molecules; visual system; topographic map; axon pathfinding; synaptic targeting
资金
- Medical Research Council [G0601182]
- Wellcome Trust [087883/Z/08/Z]
- Biotechnology and Biological Sciences Research Council [BB/M000664/1]
- French Ministry of Higher Education and Research
- Ecole Normale Superieure of Lyon
- Biotechnology and Biological Sciences Research Council [BB/M000664/1] Funding Source: researchfish
- Medical Research Council [G0601182, G0901899] Funding Source: researchfish
- Wellcome Trust [087883/Z/08/Z] Funding Source: Wellcome Trust
- BBSRC [BB/M000664/1] Funding Source: UKRI
- MRC [G0901899, G0601182] Funding Source: UKRI
The formation of visual circuitry is a multistep process that involves cell-cell interactions based on a range of molecular mechanisms. The correct implementation of individual events, including axon outgrowth and guidance, the formation of the topographic map, or the synaptic targeting of specific cellular subtypes, are prerequisites for a fully functional visual system that is able to appropriately process the information captured by the eyes. Cell adhesion molecules (CAMs) with their adhesive properties and their high functional diversity have been identified as key actors in several of these fundamental processes. Because of their growth-promoting properties, CAMs play an important role in neuritogenesis. Furthermore, they are necessary to control additional neurite development, regulating dendritic spacing and axon pathfinding. Finally, trans-synaptic interactions of CAMs ensure cell type-specific connectivity as a basis for the establishment of circuits processing distinct visual features. Recent discoveries implicating CAMs in novel mechanisms have led to a better general understanding of neural circuit formation, but also revealed an increasing complexity of their function. This review aims at describing the different levels of action for CAMs to shape neural connectivity, with a special focus on the visual system. (c) 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 569-583, 2015
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