期刊
ACS APPLIED NANO MATERIALS
卷 2, 期 12, 页码 7466-7472出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.9b01815
关键词
carbon dots; confocal microscopy; fluorescence imaging; muscle tissues; nanoparticles; worms
资金
- Council of Scientific and Industrial Research (Grant CSIR) [SRF:9/1058(07)/17-EMR-1]
- European Research Council under the European Union [340528]
- Cluster of Excellence
- DFG Research Center Nanoscale Microscopy and Molecular Physiology of the Brain
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- [SFB 937]
- European Research Council (ERC) [340528] Funding Source: European Research Council (ERC)
We introduce a carbon-dot-based fluorescent label for F-actin with high labeling specificity that allowed us to perform three-dimensional fluorescence imaging of thick muscle tissues. Actin-binding proteins play a pivotal role in the sarcomere, regulating actin-filament morphology, stability, and dynamics. We studied the morphology of Caenorhabditis elegans nematode body-wall-muscle cells as well as changes with the mutation of various actin-binding proteins. The obtained results of the study of a newly generated by us dbn-1(vit7) C. elegans mutant muscle structure are important in order to understand the development of drebrin-like protein-caused heart failure in humans.
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