期刊
NEW JOURNAL OF CHEMISTRY
卷 43, 期 47, 页码 18767-18779出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj03108a
关键词
-
资金
- National Institute of Technology Durgapur, W.B., Durgapur, India
- DST-SERB, Govt. of India [EEQ/2017/000077]
- Government of West Bengal [BT/ST/P/ST/2G44/2017]
- CSIR-HRDG, Government of India [01(2946)/18/EMR-II]
A Pt(II)-based complex [Pt(DMEEDA)Cl-2], 1 (DMEEDA = N,N-dimethyl-N'-ethylethylenediamine), was synthesized, where DMEEDA acted as the (N,N) bidentate carrier ligand. The diaqua complex [Pt(DMEEDA)(H2O)(2)](NO3)(2), 2, was obtained by the hydrolysis of dichloro complex 1. Further, its substituted complex [Pt(DMEEDA)(L-cys)](NO3), 3, and [Pt(DMEEDA)(N-ac-L-cys)], 4 (where L-cys = L-cysteine and N-ac-L-cys = N-acetyl-L-cysteine), were synthesized with amino acid L-cysteine and its acetyl derivative. The complexes were characterized via different spectroscopic techniques, such as UV-Vis, FT-IR, H-1 NMR and ESI-MS. The structure of complex 1 was determined via X-ray diffraction studies to be an orthorhombic crystal system with cell parameters a = 7.9970(2) angstrom, b = 16.9851(7) angstrom, c = 16.0460(7) angstrom and alpha = 90(degrees); beta = 90(degrees); gamma = 90(degrees) and space group (pccn). The DNA-binding properties of the complexes were investigated via gel electrophoresis, and DNA-binding constants were obtained from UV-Vis spectroscopic and fluorescence titration methods. Congruent with a significant increase in DNA fragmentation, the growth inhibition potential of the synthesized Pt(II) complexes has been remarkably higher in the hepatocarcinoma cell line (HepG2), as compared to cisplatin. Moreover, these complexes show minimal toxicity to mouse primary hepatocytes and RAW 264.7 cells in vitro.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据