期刊
ARCHIVES OF ENDOCRINOLOGY METABOLISM
卷 63, 期 6, 页码 557-567出版社
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
DOI: 10.20945/2359-3997000000185
关键词
Tissue-specific knockout; GHR; GHRKO; conditional knockout; gene disruption
资金
- National Institutes of Health/National Institute on Aging [R01AG059779, P01AG031736]
- State of Ohio's Eminent Scholar Program
- Diabetes Institute at Ohio University
- AMVETS
In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue global. In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines.
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