期刊
JOURNAL OF THE ENDOCRINE SOCIETY
卷 3, 期 12, 页码 2411-2426出版社
ENDOCRINE SOC
DOI: 10.1210/js.2019-00342
关键词
autoimmune; brown adipose tissue; cold-induced thermogenesis; hypothyroidism; infrared thermography; thyroid hormones
资金
- Nottingham University Hospitals Charity (Grant PP-Law-Nov12)
Objective: The interaction between thyroid status and brown adipose tissue (BAT) activation is complex. We assessed the effect of autoimmune hypothyroidism (ATD) in female children on BAT activation, measured using infrared thermography. Design: Twenty-six female participants (14 with ATD and 12 healthy controls) between 5 and 17 years of age attended a single study session. Thermal images were taken of the supraclavicular region before, and after, the introduction of a cool stimulus. Results: Participants with ATD had lower resting (hypothyroid, 34.9 +/- 0.7 degrees C; control, 35.4 +/- 0.5 degrees C; P = 0.03) and stimulated (hypothyroid, 35.0 +/- 0.6 degrees C; control, 35.5 +/- 0.5 degrees C; P = 0.04) supraclavicular temperatures compared with controls, but there was no difference between groups in the temperature increase with stimulation. BAT activation, calculated as the relative temperature change comparing the supraclavicular temperature to a sternal reference region, was reduced in participants with ATD (hypothyroid, 0.1 +/- 0.1 degrees C; control, 0.2 +/- 0.2 degrees C; P = 0.04). Children with ATD were frequently biochemically euthyroid due to replacement therapy, but, despite this, increased relative supraclavicular temperature was closely associated with increased TSH (r = 0.7, P = 0.01) concentrations. Conclusions: Girls with ATD had an attenuated thermogenic response to cold stimulation compared with healthy controls, but, contrary to expectation, those with suboptimal biochemical control (with higher TSH) showed increased BAT activation. This suggests that the underlying disease process may have a negative effect on BAT response, but high levels of TSH can mitigate, and even stimulate, BAT activity. In summary, thyroid status is a complex determinant of BAT activity in girls with ATD. Copyright (C) 2019 Endocrine Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据