期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 168, 期 -, 页码 13-17出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2016.12.009
关键词
Antibacterial; Silver complex; Water soluble; Triazaadamantane moiety; Schiff base ligands
资金
- NSF [DMR-1409335]
- NIH [2R25GM058903]
- U.S. Department of Energy [DEACO2-05CH11231]
- Direct For Mathematical & Physical Scien [1409335] Funding Source: National Science Foundation
- Division Of Materials Research [1409335] Funding Source: National Science Foundation
Two new silver(l) complexes, namely [Ag(qyAm)(2)](CF3SO3) (1) and [Ag(qyTAm)(2)](CF3SO3) (2), (qyAm = 2-(quinonyl)iminoadamantane, qyTAm = 2-(quinonyl)iminotriazaadamantane) have been synthesized and characterized by elemental analyses, H-1 NMR, IR, electronic absorption spectroscopy, and X-ray diffraction. The coordination geometry of the silver center in both complexes is distorted tetrahedral where their respective qyAm and qyTAm ligand bind in a bidentate fashion using the imine and quinoline nitrogen atoms. Complex 2 is soluble in water and exhibits strong antimicrobial actions on both Gram-negative (E. coli, and P. aeruginosa) and Grampositive (S. aureus) bacteria. The minimal inhibitory concentration (MIC) values for complex 2 (4, 4, and 8 mu g for E. coli, P. aeruginosa, and S. aureus, respectively) are comparable to MIC values of silver nitrate and silver sulfadiazine.(C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据