期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 175, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.06.010
关键词
Gold phosphine complexes; Anti-cancer activity; Thioredoxin reductase; Apoptosis
We report the application of cationic tri-and tetra-nuclear gold(I) phosphine complexes [Au-3(mu-dppen)(3)]X-3 and [Au-4(mu-dppa)(4)]X-4 (X = OTf, PF6) [OTf = trifluoromethanesulfonate, dppen = trans-1,2-bis(diphenylphosphino) ethene, dppa = bis(diphenylphosphino)acetylene] for cancer treatment. The results of cytotoxicity tests on four different cancer cells [prostate (DU145), cervical (HeLa), breast (MDAMB-231) and flbro sarcoma (HT1080)] indicate these complexes possess remarkable tumor cell growth inhibitory effects and high selectivity towards cancer cells. The anti-tumor mechanism of the tri-and tetra-nuclear gold(I) complexes has also been investigated.
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