期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 170, 期 -, 页码 188-194出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.02.015
关键词
Gold; Cyclometalation; Dithiolene; Biofilm; Antimicrobic; DFT
资金
- Dipartimento di Scienze Chimiche e Geologiche of the Universita degli Studi di Cagliari
- Fondazione di Sardegna
- Regione Autonoma della Sardegna (RAS) from L.R. 7 [CRP-78365]
The novel heteroleptic cyclometalated complex [Au-III(py(b)-H)(mnt)] (1; py(b)-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with Minimum Inhibitory Concentration (MIC) values of 1.56 and 3.13 mu g/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity. (C) 2017 Elsevier Inc. All rights reserved.
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