期刊
JOURNAL OF INFECTIOUS DISEASES
卷 216, 期 -, 页码 S662-S668出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix353
关键词
tuberculosis; transmission; public health
资金
- Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), Department of Health and Human Services [HHSN272201100001G]
- NIH [NIAID R01AI116787, NIAID R01AI089349, NIAID R01AI087465, NIAID K24AI114444, Emory CFAR P30AI050409, NHLBI T32 HL116271]
- Bill and Melinda Gates Foundation
High rates of tuberculosis transmission are driving the ongoing global tuberculosis epidemic, and there is a pressing need for research focused on understanding and, ultimately, halting transmission. The ongoing tuberculosis-human immunodeficiency virus (HIV) coepidemic and rising rates of drug-resistant tuberculosis in parts of the world add further urgency to this work. Success in this research will require a concerted, multidisciplinary effort on the part of tuberculosis scientists, clinicians, programs, and funders and must span the research spectrum from biomedical sciences to the social sciences, public health, epidemiology, cost-effectiveness analyses, and operations research. Heterogeneity of tuberculosis disease, both among individual patients and among communities, poses a substantial challenge to efforts to interrupt transmission. As such, it is likely that effective interventions to stop transmission will require a combination of approaches that will vary across different epidemiologic settings. This research roadmap summarizes key gaps in our current understanding of transmission, as laid out in the preceding articles in this series. We also hope that it will be a call to action for the global tuberculosis community to make a sustained commitment to tuberculosis transmission science. Halting transmission today is an essential step on the path to end tuberculosis tomorrow.
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