期刊
JOURNAL OF INFECTIOUS DISEASES
卷 217, 期 7, 页码 1139-1144出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix669
关键词
Rectal syphilis; nonhuman primate model; rhesus; SHIV; HIV; Treponema pallidum; coinfection; MSM
资金
- Centers for Disease Control and Prevention
- National Institutes of Health [AAI 12041-001-03001]
- CDC [AAI 12041-001-03001]
Among men who have sex with men (MSM), those with a diagnosis of syphilis or other rectal sexually transmitted infections (STIs) are at a higher risk for human immunodeficiency virus acquisition, which is concerning given the large increase in recently reported syphilis cases in the United States. We have developed the first nonhuman primate model for rectally transmitted syphilis by exposing simian/human immunodeficiency virus-infected and naive rhesus macaques to Treponema pallidum in the rectum. All animals showed mucosal lesions, systemic dissemination, and seroconversion (treponemal antibodies). This model would be valuable for studying the manifestations of and interventions for T. pallidum infection, with and without human immunodeficiency virus coinfection.
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